Soy and Human Health

• The Astonishing Functional Food: Soy Protein and Soy Constituents
• Soy Protein and Coronary Heart Disease
• Soy and Digestive Tract Health
• Soy Foods in Chronic Renal Disease
• How Can Soy Help Diabetes?
• Soy Protein Enhances Energy, Stamina and Sport Performance
• Soy and Cancers
• Soy and Breast Cancer
• Soy and Menopausal Symptoms
• Soy and Pre-Menstrual Syndromes
• Soy and Bone Health
• Losing Weight Healthily with Soy
• Soy and Urological Cancer
• Soy Lecithin and Human Health
• Clinical Abstracts on Soy
• Soy Clinical Reviews in Reputable Medical Journals: 1995-2002

Soy Clinical Reviews in Reputable Medical Journals (1995 -2002)

• Tonstad, S., Smerud, K., Hoie, L. (2002). A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins, and plasma total homocysteine in hypercholesterolemic subjects. Am. J. Clin. Nutr. 76: 78-84[Abstract] [Full Text]
• Boker, L. K., Van der Schouw, Y. T., De Kleijn, M. J. J., Jacques, P. F., Grobbee, D. E., Peeters, P. H. M. (2002). Intake of Dietary Phytoestrogens by Dutch Women. J. Nutr. 132: 1319-1328 [Abstract] [Full Text]
• Clarkson, T. B. (2002). Soy, Soy Phytoestrogens and Cardiovascular Disease. J. Nutr. 132: 566S-569 [Abstract] [Full Text]
• de Kleijn, M. J. J., van der Schouw, Y. T., Wilson, P. W. F., Grobbee, D. E., Jacques, P. F. (2002). Dietary Intake of Phytoestrogens Is Associated with a Favorable Metabolic Cardiovascular Risk Profile in Postmenopausal U.S. Women: The Framingham Study. J. Nutr. 132: 276-282 [Abstract] [Full Text]
• Hung, C.-J., Huang, P.-C., Lu, S.-C., Li, Y.-H., Huang, H.-B., Lin, B.-F., Chang, S.-J., Chou, H.-F. (2002). Plasma Homocysteine Levels in Taiwanese Vegetarians Are Higher than Those of Omnivores. J. Nutr. 132: 152-158 [Abstract] [Full Text]
• Meinertz, H., Nilausen, K., Hilden, J. (2002). Alcohol-Extracted, but Not Intact, Dietary Soy Protein Lowers Lipoprotein(a) Markedly. Arterioscler Thromb 22: 312-316 [Abstract] [Full Text]
• (1995). Soy Protein Reduces Total, LDL Cholesterol, Meta-Analysis Shows. Journal Watch Cardiology 1995: 7-7 [Full Text]
• (1998). 'Managing' Menopause: Alternatives to HRT. Journal Watch Women's Health 1998: 22-22 [Full Text]
• Persky, V. W, Turyk, M. E, Wang, L., Freels, S., Chatterton, R. Jr, Barnes, S., Erdman, J. Jr, Sepkovic, D. W, Bradlow, H L., Potter, S. (2002). Effect of soy protein on endogenous hormones in postmenopausal women. Am. J. Clin. Nutr. 75: 145-153 [Abstract] [Full Text]
• Adams, M. R., Golden, D. L., Anthony, M. S., Register, T. C., Williams, J. K. (2002). The Inhibitory Effect of Soy Protein Isolate on Atherosclerosis in Mice Does Not Require the Presence of LDL Receptors or Alteration of Plasma Lipoproteins. J. Nutr. 132: 43-49 [Abstract] [Full Text]
• Anderson, J. W, Konz, E. C, Frederich, R. C, Wood, C. L (2001). Long-term weight-loss maintenance: a meta-analysis of US studies. Am. J. Clin. Nutr. 74: 579-584 [Abstract] [Full Text]
• Evans, M. J., Eckert, A., Lai, K., Adelman, S. J., Harnish, D. C. (2001). Reciprocal Antagonism Between Estrogen Receptor and NF-{kappa}B Activity In Vivo. Circulation Research 89: 823-830 [Abstract] [Full Text]
• Rajaram, S., Burke, K., Connell, B., Myint, T., Sabate, J. (2001). A Monounsaturated Fatty Acid-Rich Pecan-Enriched Diet Favorably Alters the Serum Lipid Profile of Healthy Men and Women. J. Nutr. 131: 2275-2279 [Abstract] [Full Text]
• Dent, S. B., Peterson, C. T., Brace, L. D., Swain, J. H., Reddy, M. B., Hanson, K. B., Robinson, J. G., Alekel, D. L. (2001). Soy Protein Intake by Perimenopausal Women Does Not Affect Circulating Lipids and Lipoproteins or Coagulation and Fibrinolytic Factors. J. Nutr. 131: 2280-2287 [Abstract] [Full Text]
• Davis, S. R (2001). Phytoestrogen therapy for menopausal symptoms?. BMJ 323: 354-355 [Full Text]
• Jenkins, D. J., Kendall, C. W., Vidgen, E., Augustin, L. S., van Erk, M., Geelen, A., Parker, T., Faulkner, D., Vuksan, V., Josse, R. G, Leiter, L. A, Connelly, P. W (2001). High-protein diets in hyperlipidemia: effect of wheat gluten on serum lipids, uric acid, and renal function. Am. J. Clin. Nutr. 74: 57-63 [Abstract] [Full Text]
• Teede, H. J., Dalais, F. S., Kotsopoulos, D., Liang, Y.-L., Davis, S., McGrath, B. P. (2001). Dietary Soy Has Both Beneficial and Potentially Adverse Cardiovascular Effects: A Placebo-Controlled Study in Men and Postmenopausal Women. J Clin Endocrinol Metab 86: 3053-3060 [Abstract] [Full Text]
• de Kleijn, M. J. J., van der Schouw, Y. T., Wilson, P. W. F., Adlercreutz, H., Mazur, W., Grobbee, D. E., Jacques, P. F. (2001). Intake of Dietary Phytoestrogens Is Low in Postmenopausal Women in the United States: The Framingham Study1-4. J. Nutr. 131: 1826-1832 [Abstract] [Full Text]
• Brown, N. M., Setchell, K. D. R. (2001). Animal Models Impacted by Phytoestrogens in Commercial Chow: Implications for Pathways Influenced by Hormones. Lab Invest 81: 735-747 [Abstract] [Full Text]
• Hermansen, K., Sndergaard, M., Hie, L., Carstensen, M., Brock, B. (2001). Beneficial Effects of a Soy-Based Dietary Supplement on Lipid Levels and Cardiovascular Risk Markers in Type 2 Diabetic Subjects. Diabetes Care 24: 228-233 [Abstract] [Full Text]
• Erdman, J. W. (1995). Control of Serum Lipids with Soy Protein. N Engl J Med 333: 313-315 [Full Text]
• Krauss, R. M., Chait, A., Stone, N. J., Anderson, J. W., Johnstone, B. M., Cook-Newell, M. E. (1995). Soy Protein and Serum Lipids. N Engl J Med 333: 1715-1716 [Full Text]
• Krauss, R. M., Chait, A., Stone, N. J., Anderson, J. W., Johnstone, B. M., Cook-Newell, M. E. (1995). Soy Protein and Serum Lipids. N Engl J Med 333: 1715-1716 [Full Text]
• Pan, W., Ikeda, K., Takebe, M., Yamori, Y. (2001). Genistein, Daidzein and Glycitein Inhibit Growth and DNA Synthesis of Aortic Smooth Muscle Cells from Stroke-Prone Spontaneously Hypertensive Rats. J. Nutr. 131: 1154-1158 [Abstract] [Full Text]
• Goodman-Gruen, D., Kritz-Silverstein, D. (2001). Usual Dietary Isoflavone Intake Is Associated with Cardiovascular Disease Risk Factors in Postmenopausal Women. J. Nutr. 131: 1202-1206 [Abstract] [Full Text]
• Lichtenstein, A. H (2001). Got soy?. Am. J. Clin. Nutr. 73: 667-668 [Full Text]
• Gardner, C. D, Newell, K. A, Cherin, R., Haskell, W. L (2001). The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. Am. J. Clin. Nutr. 73: 728-735 [Abstract] [Full Text]
• Wangen, K. E, Duncan, A. M, Xu, X., Kurzer, M. S (2001). Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am. J. Clin. Nutr. 73: 225-231 [Abstract] [Full Text]
• Lu, L.-J. W., Anderson, K. E., Grady, J. J., Kohen, F., Nagamani, M. (2000). Decreased Ovarian Hormones during a Soya Diet: Implications for Breast Cancer Prevention. Cancer Res 60: 4112-4121 [Abstract] [Full Text]
• Clarkson, T. B., Anthony, M. S., Morgan, T. M. (2001). Inhibition of Postmenopausal Atherosclerosis Progression: A Comparison of the Effects of Conjugated Equine Estrogens and Soy Phytoestrogens. J Clin Endocrinol Metab 86: 41-47 [Abstract] [Full Text]
• Krauss, R. M., Eckel, R. H., Howard, B., Appel, L. J., Daniels, S. R., Deckelbaum, R. J., Erdman, J. W. Jr, Kris-Etherton, P., Goldberg, I. J., Kotchen, T. A., Lichtenstein, A. H., Mitch, W. E., Mullis, R., Robinson, K., Wylie-Rosett, J., St. Jeor, S., Suttie, J., Tribble, D. L., Bazzarre, T. L. (2001). AHA Scientific Statement: AHA Dietary Guidelines: Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association. J. Nutr. 131: 132-146 [Full Text]
• Theriault, A., Wang, Q., Van Iderstine, S. C., Chen, B., Franke, A. A., Adeli, K. (2000). Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid. J. Lipid Res. 41: 1969-1979 [Abstract] [Full Text]
• Middleton, E. Jr., Kandaswami, C., Theoharides, T. C. (2000). The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer. Pharmacological Reviews 52: 673-751 [Abstract] [Full Text]
• Teixeira, S. R, Hannum, S., Erdman, J. W Jr, Potter, S. M, Hasler, C. M (2000). Reply to DS Kalman and CM Colker. Am. J. Clin. Nutr. 72: 1588-1589 [Full Text]
• Erdman, J. W. Jr (2000). Soy Protein and Cardiovascular Disease : A Statement for Healthcare Professionals From the Nutrition Committee of the AHA. Circulation 102: 2555-2559 [Full Text]
• Krauss, R. M., Eckel, R. H., Howard, B., Appel, L. J., Daniels, S. R., Deckelbaum, R. J., Erdman, J. W. Jr, Kris-Etherton, P., Goldberg, I. J., Kotchen, T. A., Lichtenstein, A. H., Mitch, W. E., Mullis, R., Robinson, K., Wylie-Rosett, J., St. Jeor, S., Suttie, J., Tribble, D. L., Bazzarre, T. L. (2000). AHA Dietary Guidelines : Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association. Stroke 31: 2751-2766 [Full Text]
• Mesiano, S., Katz, S. L., Lee, J. Y., Jaffe, R. B. (1999). Phytoestrogens Alter Adrenocortical Function: Genistein and Daidzein Suppress Glucocorticoid and Stimulate Androgen Production by Cultured Adrenal Cortical Cells. J Clin Endocrinol Metab 84: 2443-2448 [Abstract] [Full Text]
• Nestel, P. J., Pomeroy, S., Kay, S., Komesaroff, P., Behrsing, J., Cameron, J. D., West, L. (1999). Isoflavones from Red Clover Improve Systemic Arterial Compliance But Not Plasma Lipids in Menopausal Women. J Clin Endocrinol Metab 84: 895-898 [Abstract] [Full Text]
• Murkies, A. L., Wilcox, G., Davis, S. R. (1998). Phytoestrogens. J Clin Endocrinol Metab 83: 297-303 [Abstract] [Full Text]
• Ishimi, Y., Miyaura, C., Ohmura, M., Onoe, Y., Sato, T., Uchiyama, Y., Ito, M., Wang, X., Suda, T., Ikegami, S. (1999). Selective Effects of Genistein, a Soybean Isoflavone, on B-Lymphopoiesis and Bone Loss Caused by Estrogen Deficiency. Endocrinology 140: 1893-1900 [Abstract] [Full Text]
• Krauss, R. M., Eckel, R. H., Howard, B., Appel, L. J., Daniels, S. R., Deckelbaum, R. J., Erdman, J. W. Jr, Kris-Etherton, P., Goldberg, I. J., Kotchen, T. A., Lichtenstein, A. H., Mitch, W. E., Mullis, R., Robinson, K., Wylie-Rosett, J., St. Jeor, S., Suttie, J., Tribble, D. L., Bazzarre, T. L. (2000). AHA Dietary Guidelines : Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association. Circulation 102: 2284-2299 [Full Text]
• Damasceno, N. R. T., Goto, H., Rodrigues, F. M. D., Dias, C. T. S., Okawabata, F. S., Abdalla, D. S. P., Gidlund, M. (2000). Soy Protein Isolate Reduces the Oxidizability of LDL and the Generation of Oxidized LDL Autoantibodies in Rabbits with Diet-Induced Atherosclerosis. J. Nutr. 130: 2641-2647 [Abstract] [Full Text]
• Nagata, C. (2000). Ecological study of the association between soy product intake and mortality from cancer and heart disease in Japan. Int. J. Epidemiol. 29: 832-836 [Abstract] [Full Text]
• Lamon-Fava, S. (2000). Genistein Activates Apolipoprotein A-I Gene Expression in the Human Hepatoma Cell Line Hep G2. J. Nutr. 130: 2489-2492 [Abstract] [Full Text]
• Lovati, M. R., Manzoni, C., Gianazza, E., Arnoldi, A., Kurowska, E., Carroll, K. K., Sirtori, C. R. (2000). Soy Protein Peptides Regulate Cholesterol Homeostasis in Hep G2 Cells. J. Nutr. 130: 2543-2549 [Abstract] [Full Text]
• Ho, S. C., Woo, J. L. F., Leung, S. S. F., Sham, A. L. K., Lam, T. H., Janus, E. D. (2000). Intake of Soy Products Is Associated with Better Plasma Lipid Profiles in the Hong Kong Chinese Population. J. Nutr. 130: 2590-2593 [Abstract] [Full Text]
• Peluso, M. R., Winters, T. A., Shanahan, M. F., Banz, W. J. (2000). A Cooperative Interaction between Soy Protein and Its Isoflavone-Enriched Fraction Lowers Hepatic Lipids in Male Obese Zucker Rats and Reduces Blood Platelet Sensitivity in Male Sprague-Dawley Rats. J. Nutr. 130: 2333-2342 [Abstract] [Full Text]
• Pinkerton, J. V., Santen, R. (1999). Alternatives to the Use of Estrogen in Postmenopausal Women. Endocr Rev 20: 308-320 [Abstract] [Full Text]
• Merz-Demlow, B. E, Duncan, A. M, Wangen, K. E, Xu, X., Carr, T. P, Phipps, W. R, Kurzer, M. S (2000). Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. Am. J. Clin. Nutr. 71: 1462-1469 [Abstract] [Full Text]
• Teixeira, S. R, Potter, S. M, Weigel, R., Hannum, S., Erdman, J. W Jr, Hasler, C. M (2000). Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men. Am. J. Clin. Nutr. 71: 1077-1084 [Abstract] [Full Text]
• Greaves, K. A., Wilson, M. D., Rudel, L. L., Williams, J. K., Wagner, J. D. (2000). Consumption of Soy Protein Reduces Cholesterol Absorption Compared to Casein Protein Alone or Supplemented with an Isoflavone Extract or Conjugated Equine Estrogen in Ovariectomized Cynomolgus Monkeys. J. Nutr. 130: 820-826 [Abstract] [Full Text]
• Anthony, M. S. (2000). Soy and Cardiovascular Disease: Cholesterol Lowering and Beyond. J. Nutr. 130: 662-662 [Full Text]
• Burke, G. L., Vitolins, M. Z., Bland, D. (2000). Soybean Isoflavones as an Alternative to Traditional Hormone Replacement Therapy: Are We There Yet?. J. Nutr. 130: 664-664 [Full Text]
• (2000). Oral Presentation Abstracts. J. Nutr. 130: 666-666 [Full Text]
• Woo, K. S., Chook, P., Raitakari, O. T., McQuillan, B., Feng, J. Z., Celermajer, D. S. (1999). Westernization of Chinese Adults and Increased Subclinical Atherosclerosis. Arterioscler Thromb 19: 2487-2493 [Abstract] [Full Text]
• Anderson, J. W, Hanna, T. J (1999). Whole grains and protection against coronary heart disease: what are the active components and mechanisms?. Am. J. Clin. Nutr. 70: 307-308 [Full Text]
• Kushi, L. H, Meyer, K. A, Jacobs, D. R Jr (1999). Cereals, legumes, and chronic disease risk reduction: evidence from epidemiologic studies. Am. J. Clin. Nutr. 70: 451S-458 [Abstract] [Full Text]
• Anderson, J. W, Smith, B. M, Washnock, C. S (1999). Cardiovascular and renal benefits of dry bean and soybean intake. Am. J. Clin. Nutr. 70: 464S-474 [Abstract] [Full Text]
• Kris-Etherton, P. M, Yu-Poth, S., Sabate, J., Ratcliffe, H. E, Zhao, G., Etherton, T. D (1999). Nuts and their bioactive constituents: effects on serum lipids and other factors that affect disease risk. Am. J. Clin. Nutr. 70: 504S-511 [Abstract] [Full Text]
• Segasothy, M., Phillips, P.A. (1999). Vegetarian diet: panacea for modern lifestyle diseases?. QJ Med 92: 531-544 [Abstract] [Full Text]
• Kurzer, M. S., Xu, X. (1997). DIETARY PHYTOESTROGENS. Annu. Rev. Nutr. 17: 353-381 [Abstract] [Full Text]
• Hu, F. B, Stampfer, M. J, Manson, J. E, Rimm, E., Colditz, G. A, Speizer, F. E, Hennekens, C. H, Willett, W. C (1999). Dietary protein and risk of ischemic heart disease in women. Am. J. Clin. Nutr. 70: 221-227 [Abstract] [Full Text]
• Vuksan, V., Jenkins, D. J., Vidgen, E., Ransom, T. P., Ng, M. K, Culhane, C. T, O'Connor, D. (1999). A novel source of wheat fiber and protein: effects on fecal bulk and serum lipids. Am. J. Clin. Nutr. 69: 226-230 [Abstract] [Full Text]
• Greaves, K. A., Parks, J. S., Williams, J. K., Wagner, J. D. (1999). Intact Dietary Soy Protein, but Not Adding an Isoflavone-Rich Soy Extract to Casein, Improves Plasma Lipids in Ovariectomized Cynomolgus Monkeys. J. Nutr. 129: 1585-1592 [Abstract] [Full Text]
• Anderson, J. W., Hanna, T. J. (1999). Impact of Nondigestible Carbohydrates on Serum Lipoproteins and Risk for Cardiovascular Disease. J. Nutr. 129: 1457-1457 [Abstract] [Full Text]
• Anderson, J. W., Hanna, T. J. (1999). Impact of Nondigestible Carbohydrates on Serum Lipoproteins and Risk for Cardiovascular Disease. J. Nutr. 129: 1457-1457 [Abstract] [Full Text]
• Jenkins, D. J., Kendall, C. W., Vidgen, E., Agarwal, S., Rao, A V., Rosenberg, R. S, Diamandis, E. P, Novokmet, R., Mehling, C. C, Perera, T., Griffin, L. C, Cunnane, S. C (1999). Health aspects of partially defatted flaxseed, including effects on serum lipids, oxidative measures, and ex vivo androgen and progestin activity: a controlled crossover trial. Am. J. Clin. Nutr. 69: 395-402 [Abstract] [Full Text]
• Nilausen, K., Meinertz, H. (1999). Lipoprotein(a) and dietary proteins: casein lowers lipoprotein(a) concentrations as compared with soy protein. Am. J. Clin. Nutr. 69: 419-425 [Abstract] [Full Text]
• Zhang, Y., Wang, G.-J., Song, T. T., Murphy, P. A., Hendrich, S. (1999). Urinary Disposition of the Soybean Isoflavones Daidzein, Genistein and Glycitein Differs among Humans with Moderate Fecal Isoflavone Degradation Activity. J. Nutr. 129: 957-962 [Abstract] [Full Text]
• Setchell, K. D. R., Cassidy, A. (1999). Dietary Isoflavones: Biological Effects and Relevance to Human Health. J. Nutr. 129: 758-758 [Abstract] [Full Text]
• Kirk, E. A., Sutherland, P., Wang, S. A., Chait, A., LeBoeuf, R. C. (1998). Dietary Isoflavones Reduce Plasma Cholesterol and Atherosclerosis in C57BL/6 Mice but not LDL Receptor-Deficient Mice. J. Nutr. 128: 954-959 [Abstract] [Full Text]
• Ni, W., Tsuda, Y., Sakono, M., Imaizumi, K. (1998). Dietary Soy Protein Isolate, Compared with Casein, Reduces Atherosclerotic Lesion Area in Apolipoprotein E-Deficient Mice. J. Nutr. 128: 1884-1889 [Abstract] [Full Text]
• Anthony, M. S., Clarkson, T. B., Bullock, B. C., Wagner, J. D. (1997). Soy Protein Versus Soy Phytoestrogens in the Prevention of Diet-Induced Coronary Artery Atherosclerosis of Male Cynomolgus Monkeys. Arterioscler Thromb 17: 2524-2531 [Abstract] [Full Text]
• Nestel, P. J., Yamashita, T., Sasahara, T., Pomeroy, S., Dart, A., Komesaroff, P., Owen, A., Abbey, M. (1997). Soy Isoflavones Improve Systemic Arterial Compliance but Not Plasma Lipids in Menopausal and Perimenopausal Women. Arterioscler Thromb 17: 3392-3398 [Abstract] [Full Text]
• Lichtenstein, A. H. (1998). Soy Protein, Isoflavones and Cardiovascular Disease Risk. J. Nutr. 128: 1589-1592 [Abstract] [Full Text]
• Wilson, T. A., Behr, S. R., Nicolosi, R. J. (1998). Addition of Guar Gum and Soy Protein Increases the Efficacy of the American Heart Association (AHA) Step I Cholesterol-Lowering Diet without Reducing High Density Lipoprotein Cholesterol Levels in Non-Human Primates. J. Nutr. 128: 1429-1433 [Abstract] [Full Text]
• Tovar-Palacio, C., Potter, S. M., Hafermann, J. C., Shay, N. F. (1998). Intake of Soy Protein and Soy Protein Extracts Influences Lipid Metabolism and Hepatic Gene Expression in Gerbils. J. Nutr. 128: 839-842 [Abstract] [Full Text]
• Hodgson, J. M., Puddey, I. B., Beilin, L. J., Mori, T. A., Croft, K. D. (1998). Supplementation with Isoflavonoid Phytoestrogens Does Not Alter Serum Lipid Concentrations: A Randomized Controlled Trial in Humans. J. Nutr. 128: 728-732 [Abstract] [Full Text]
• Nagata, C., Takatsuka, N., Kurisu, Y., Shimizu, H. (1998). Decreased Serum Total Cholesterol Concentration Is Associated with High Intake of Soy Products in Japanese Men and Women. J. Nutr. 128: 209-213 [Abstract] [Full Text]
• Zhao, X.-T., McCamish, M. A., Miller, R. H., Wang, L., Lin, H. C. (1997). Intestinal Transit and Absorption of Soy Protein In Dogs Depend On Load and Degree of Protein Hydrolysis. J. Nutr. 127: 2350-2356 [Abstract] [Full Text]
• Tikkanen, M. J., Wahala, K., Ojala, S., Vihma, V., Adlercreutz, H. (1998). Effect of soybean phytoestrogen intake on low density lipoprotein oxidationresistance. Proc. Natl. Acad. Sci. U. S. A. 95: 3106-3110 [Abstract] [Full Text]